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4e18
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==Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin== | ==Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin== | ||
| - | <StructureSection load='4e18' size='340' side='right' caption='[[4e18]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='4e18' size='340' side='right'caption='[[4e18]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4e18]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4e18]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E18 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.403Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e18 OCA], [https://pdbe.org/4e18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e18 RCSB], [https://www.ebi.ac.uk/pdbsum/4e18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e18 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/VINC_CHICK VINC_CHICK] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:15229287</ref> <ref>PMID:20584916</ref> <ref>PMID:20086044</ref> |
==See Also== | ==See Also== | ||
| + | *[[Catenin 3D structures|Catenin 3D structures]] | ||
*[[Vinculin|Vinculin]] | *[[Vinculin|Vinculin]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Gallus gallus]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bankston | + | [[Category: Mus musculus]] |
| - | [[Category: Cadwell | + | [[Category: Bankston LA]] |
| - | [[Category: Choi | + | [[Category: Cadwell GW]] |
| - | [[Category: Liddington | + | [[Category: Choi H-J]] |
| - | [[Category: Pokutta | + | [[Category: Liddington RC]] |
| - | [[Category: Weis | + | [[Category: Pokutta S]] |
| - | + | [[Category: Weis WI]] | |
| - | + | ||
Current revision
Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin
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