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2ypo

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==3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site==
==3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site==
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<StructureSection load='2ypo' size='340' side='right' caption='[[2ypo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='2ypo' size='340' side='right'caption='[[2ypo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ypo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ypo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ypp|2ypp]], [[2ypq|2ypq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypo OCA], [https://pdbe.org/2ypo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypo RCSB], [https://www.ebi.ac.uk/pdbsum/2ypo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypo OCA], [http://pdbe.org/2ypo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ypo RCSB], [http://www.ebi.ac.uk/pdbsum/2ypo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AROG_MYCTU AROG_MYCTU]] Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.<ref>PMID:16288916</ref>
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[https://www.uniprot.org/uniprot/AROG_MYCTU AROG_MYCTU] Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.<ref>PMID:16288916</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[DAHP synthase|DAHP synthase]]
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*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
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[[Category: Large Structures]]
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[[Category: Baker, E N]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Blackmore, N J]]
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[[Category: Baker EN]]
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[[Category: Hutton, R D]]
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[[Category: Blackmore NJ]]
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[[Category: Jameson, G B]]
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[[Category: Hutton RD]]
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[[Category: Jiao, W]]
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[[Category: Jameson GB]]
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[[Category: Parker, E J]]
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[[Category: Jiao W]]
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[[Category: Reichau, S]]
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[[Category: Parker EJ]]
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[[Category: Aromatic amino acid biosynth allostery]]
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[[Category: Reichau S]]
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[[Category: Shikimate pathway]]
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[[Category: Transferase]]
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Current revision

3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site

PDB ID 2ypo

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