This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1l4v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:06, 3 April 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1l4v.gif|left|200px]]
 
-
{{Structure
+
==SOLUTION STRUCTURE OF SAPECIN==
-
|PDB= 1l4v |SIZE=350|CAPTION= <scene name='initialview01'>1l4v</scene>
+
<StructureSection load='1l4v' size='340' side='right'caption='[[1l4v]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1l4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L4V FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [https://pdbe.org/1l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB], [https://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l4v ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l4v OCA], [http://www.ebi.ac.uk/pdbsum/1l4v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l4v RCSB]</span>
+
[https://www.uniprot.org/uniprot/SAPE_SARPE SAPE_SARPE] Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.
-
}}
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
'''SOLUTION STRUCTURE OF SAPECIN'''
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/1l4v_consurf.spt"</scriptWhenChecked>
-
==Overview==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
The solution conformation of an antibacterial protein sapecin has been determined by 1H nuclear magnetic resonance (NMR) and dynamical simulated annealing calculations. It has been shown that the polypeptide fold consists of one flexible loop (residues 4-12), one helix (residues 15-23), and two extended strands (residues 24-31 and 34-40). It was found that the tertiary structure of sapecin is completely different from that of rabbit neutrophil defensin NP-5, which is homologous to sapecin in the amino acid sequences and also has the antibacterial activity. The three-dimensional structure determination has revealed that a basic-residue rich region and the hydrophobic surface face each other on the surface of sapecin.
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l4v ConSurf].
-
1L4V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sarcophaga_peregrina Sarcophaga peregrina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L4V OCA].
+
<div style="clear:both"></div>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
1H nuclear magnetic resonance study of the solution conformation of an antibacterial protein, sapecin., Hanzawa H, Shimada I, Kuzuhara T, Komano H, Kohda D, Inagaki F, Natori S, Arata Y, FEBS Lett. 1990 Sep 3;269(2):413-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2401368 2401368]
+
[[Category: Large Structures]]
[[Category: Sarcophaga peregrina]]
[[Category: Sarcophaga peregrina]]
-
[[Category: Single protein]]
+
[[Category: Arata Y]]
-
[[Category: Arata, Y.]]
+
[[Category: Hanzawa H]]
-
[[Category: Hanzawa, H.]]
+
[[Category: Inagaki F]]
-
[[Category: Inagaki, F.]]
+
[[Category: Iwai H]]
-
[[Category: Iwai, H.]]
+
[[Category: Kohda D]]
-
[[Category: Kohda, D.]]
+
[[Category: Komano H]]
-
[[Category: Komano, H.]]
+
[[Category: Kuzuhara T]]
-
[[Category: Kuzuhara, T.]]
+
[[Category: Natori S]]
-
[[Category: Natori, S.]]
+
[[Category: Shimada I]]
-
[[Category: Shimada, I.]]
+
[[Category: Takeuchi K]]
-
[[Category: Takeuchi, K.]]
+
-
[[Category: antibacterial protein,insect defensin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:58:02 2008''
+

Current revision

SOLUTION STRUCTURE OF SAPECIN

PDB ID 1l4v

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l4v"
Personal tools