3zfw

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==Crystal structure of the TPR domain of kinesin light chain 2 in complex with a tryptophan-acidic cargo peptide==
==Crystal structure of the TPR domain of kinesin light chain 2 in complex with a tryptophan-acidic cargo peptide==
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<StructureSection load='3zfw' size='340' side='right' caption='[[3zfw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3zfw' size='340' side='right'caption='[[3zfw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zfw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZFW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zfw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZFW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zfw OCA], [http://pdbe.org/3zfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zfw RCSB], [http://www.ebi.ac.uk/pdbsum/3zfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zfw ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zfw OCA], [https://pdbe.org/3zfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zfw RCSB], [https://www.ebi.ac.uk/pdbsum/3zfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zfw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PKHM2_HUMAN PKHM2_HUMAN]] May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.<ref>PMID:15905402</ref>
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[https://www.uniprot.org/uniprot/KLC2_MOUSE KLC2_MOUSE] Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends.[UniProtKB:Q9H0B6]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Kinesin|Kinesin]]
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Dodding, M P]]
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[[Category: Mus musculus]]
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[[Category: Lamprecht, A]]
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[[Category: Dodding MP]]
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[[Category: Pernigo, S]]
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[[Category: Lamprecht A]]
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[[Category: Steiner, R A]]
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[[Category: Pernigo S]]
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[[Category: Hydrolase]]
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[[Category: Steiner RA]]
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[[Category: Kinesin-cargo recognition]]
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[[Category: Motor protein]]
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[[Category: Salmonella]]
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[[Category: Tpr domain]]
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Current revision

Crystal structure of the TPR domain of kinesin light chain 2 in complex with a tryptophan-acidic cargo peptide

PDB ID 3zfw

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