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4rmf

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==Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target==
==Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target==
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<StructureSection load='4rmf' size='340' side='right' caption='[[4rmf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4rmf' size='340' side='right'caption='[[4rmf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rmf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RMF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rmf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RMF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SY:2,2-BIS(HYDROXYMETHYL)PROPANE-1,3-DIOL'>3SY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate--tRNA(Asn)_ligase Aspartate--tRNA(Asn) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.23 6.1.1.23] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SY:2,2-BIS(HYDROXYMETHYL)PROPANE-1,3-DIOL'>3SY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmf OCA], [http://pdbe.org/4rmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rmf RCSB], [http://www.ebi.ac.uk/pdbsum/4rmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmf OCA], [https://pdbe.org/4rmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rmf RCSB], [https://www.ebi.ac.uk/pdbsum/4rmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYDND_MYCS2 SYDND_MYCS2]] Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).[HAMAP-Rule:MF_00044]
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[https://www.uniprot.org/uniprot/SYDND_MYCS2 SYDND_MYCS2] Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).[HAMAP-Rule:MF_00044]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4rmf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4rmf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Besra, G S]]
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[[Category: Large Structures]]
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[[Category: Cox, J A.G]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Futterer, K]]
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[[Category: Besra GS]]
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[[Category: Gurcha, S S]]
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[[Category: Cox JAG]]
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[[Category: Veeraraghavan, U]]
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[[Category: Futterer K]]
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[[Category: Alpha and beta protein]]
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[[Category: Gurcha SS]]
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[[Category: Ligase]]
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[[Category: Veeraraghavan U]]
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[[Category: Trna]]
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[[Category: Trna synthetase]]
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Current revision

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

PDB ID 4rmf

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