This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4g4o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (20:24, 19 October 2022) (edit) (undo)
 
Line 1: Line 1:
==MutM containing M77A mutation bound to oxoG-containing DNA==
==MutM containing M77A mutation bound to oxoG-containing DNA==
-
<StructureSection load='4g4o' size='340' side='right' caption='[[4g4o]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
+
<StructureSection load='4g4o' size='340' side='right'caption='[[4g4o]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4g4o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G4O FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4g4o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G4O FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=TX2:5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}THYMIDINE'>TX2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=TX2:5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}THYMIDINE'>TX2</scene></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4o OCA], [https://pdbe.org/4g4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g4o RCSB], [https://www.ebi.ac.uk/pdbsum/4g4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g4o ProSAT]</span></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g4n|4g4n]], [[4g4q|4g4q]], [[4g4r|4g4r]]</td></tr>
+
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mutM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 ATCC 12980])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g4o OCA], [http://pdbe.org/4g4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g4o RCSB], [http://www.ebi.ac.uk/pdbsum/4g4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g4o ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
+
[https://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 20:
==See Also==
==See Also==
-
*[[DNA glycosylase|DNA glycosylase]]
+
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Atcc 12980]]
+
[[Category: Geobacillus stearothermophilus]]
-
[[Category: DNA-formamidopyrimidine glycosylase]]
+
[[Category: Large Structures]]
-
[[Category: Qi, Y]]
+
[[Category: Qi Y]]
-
[[Category: Sung, R J]]
+
[[Category: Sung RJ]]
-
[[Category: Verdine, G L]]
+
[[Category: Verdine GL]]
-
[[Category: Zhang, M]]
+
[[Category: Zhang M]]
-
[[Category: Base extrusion]]
+
-
[[Category: Disulfide crosslinking]]
+
-
[[Category: Dna glycosylase]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Hydrolase-dna complex]]
+
-
[[Category: Lesion recognition]]
+

Current revision

MutM containing M77A mutation bound to oxoG-containing DNA

PDB ID 4g4o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4g4o"
Personal tools