4pbv

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==Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC==
==Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC==
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<StructureSection load='4pbv' size='340' side='right' caption='[[4pbv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4pbv' size='340' side='right'caption='[[4pbv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pbv]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PBV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pbv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PBV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yd4|2yd4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pbv OCA], [https://pdbe.org/4pbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pbv RCSB], [https://www.ebi.ac.uk/pdbsum/4pbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pbv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pbv OCA], [http://pdbe.org/4pbv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pbv RCSB], [http://www.ebi.ac.uk/pdbsum/4pbv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pbv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NTRK3_CHICK NTRK3_CHICK]] Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase and PLCG1. The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells.
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[https://www.uniprot.org/uniprot/NTRK3_CHICK NTRK3_CHICK] Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase and PLCG1. The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4pbv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4pbv" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[TrkB tyrosine kinase receptor|TrkB tyrosine kinase receptor]]
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*[[Tyrosine kinase receptor 3D structures|Tyrosine kinase receptor 3D structures]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Gallus gallus]]
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[[Category: Aricescu, A R]]
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[[Category: Large Structures]]
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[[Category: Coles, C H]]
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[[Category: Aricescu AR]]
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[[Category: Craig, A M]]
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[[Category: Coles CH]]
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[[Category: Elegheert, J]]
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[[Category: Craig AM]]
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[[Category: Jones, E Y]]
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[[Category: Elegheert J]]
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[[Category: Lu, W]]
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[[Category: Jones EY]]
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[[Category: Mitakidis, N]]
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[[Category: Lu W]]
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[[Category: Nakagawa, T]]
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[[Category: Mitakidis N]]
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[[Category: Stoker, A W]]
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[[Category: Nakagawa T]]
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[[Category: Zhang, P]]
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[[Category: Stoker AW]]
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[[Category: Signaling protein]]
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[[Category: Zhang P]]
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[[Category: Synapse cell signalling cell surface receptor]]
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Current revision

Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC

PDB ID 4pbv

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