4n9n

<StructureSection load='4n9n' size='340' side='right' caption='[[4n9n]], [[Resolution|resolution]] 2.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[4n9n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9N FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9n OCA], [http://pdbe.org/4n9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9n RCSB], [http://www.ebi.ac.uk/pdbsum/4n9n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9n ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/UPC2_YEAST UPC2_YEAST]] Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.<ref>PMID:11238402</ref> <ref>PMID:11292809</ref> <ref>PMID:11533229</ref> <ref>PMID:12077145</ref> <ref>PMID:12673627</ref>

== References ==

<references/>

[[Category: Im, Y J]]

[[Category: Yang, H]]

[[Category: Ergosterol binding]]

[[Category: Fungal nuclear receptor-like transcription factor]]

[[Category: Nucleus]]

[[Category: Transcription]]