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3mdf

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==Crystal structure of the RRM domain of Cyclophilin 33==
==Crystal structure of the RRM domain of Cyclophilin 33==
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<StructureSection load='3mdf' size='340' side='right' caption='[[3mdf]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='3mdf' size='340' side='right'caption='[[3mdf]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MDF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mdf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MDF FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPIE, CYP33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdf OCA], [https://pdbe.org/3mdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mdf RCSB], [https://www.ebi.ac.uk/pdbsum/3mdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdf OCA], [http://pdbe.org/3mdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mdf RCSB], [http://www.ebi.ac.uk/pdbsum/3mdf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PPIE_HUMAN PPIE_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.
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[https://www.uniprot.org/uniprot/PPIE_HUMAN PPIE_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdf_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdf_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Cyclophilin|Cyclophilin]]
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Chang, P Y]]
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[[Category: Chang PY]]
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[[Category: Cleary, M L]]
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[[Category: Cleary ML]]
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[[Category: Glass, K C]]
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[[Category: Glass KC]]
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[[Category: Gozani, O]]
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[[Category: Gozani O]]
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[[Category: Hom, R A]]
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[[Category: Hom RA]]
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[[Category: Ismagilov, R F]]
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[[Category: Ismagilov RF]]
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[[Category: Kutateladze, T G]]
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[[Category: Kutateladze TG]]
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[[Category: Mussleman, C A]]
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[[Category: Mussleman CA]]
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[[Category: Roy, S]]
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[[Category: Roy S]]
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[[Category: Seleznevia, A I]]
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[[Category: Seleznevia AI]]
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[[Category: Cyp33]]
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[[Category: Isomerase]]
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[[Category: Mll]]
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[[Category: Mrna processing]]
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[[Category: Mrna splicing]]
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[[Category: Nucleus]]
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[[Category: Phd finger]]
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[[Category: Rna binding protein]]
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[[Category: Rna-binding]]
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[[Category: Rotamase]]
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[[Category: Rrm domain]]
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[[Category: Spliceosome]]
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Current revision

Crystal structure of the RRM domain of Cyclophilin 33

PDB ID 3mdf

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