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3lev

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==HIV-1 antibody 2F5 in complex with epitope scaffold ES2==
==HIV-1 antibody 2F5 in complex with epitope scaffold ES2==
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<StructureSection load='3lev' size='340' side='right' caption='[[3lev]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3lev' size='340' side='right'caption='[[3lev]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lev]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LEV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lev]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LEV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3les|3les]], [[3lex|3lex]], [[3ley|3ley]], [[1tji|1tji]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIGMA FACTOR SIGA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lev OCA], [https://pdbe.org/3lev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lev RCSB], [https://www.ebi.ac.uk/pdbsum/3lev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lev ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lev OCA], [http://pdbe.org/3lev PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lev RCSB], [http://www.ebi.ac.uk/pdbsum/3lev PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lev ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q9EZJ8_THEAQ Q9EZJ8_THEAQ]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity).[RuleBase:RU000715]
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[https://www.uniprot.org/uniprot/SIGA_THEAQ SIGA_THEAQ] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.[HAMAP-Rule:MF_00963]<ref>PMID:11114902</ref> <ref>PMID:11931761</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/le/3lev_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/le/3lev_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Sigma factor|Sigma factor]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of antibody|3D structures of antibody]]
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 25104]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Baker, D]]
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[[Category: Thermus aquaticus]]
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[[Category: Guenaga, F J]]
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[[Category: Baker D]]
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[[Category: Kwong, P D]]
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[[Category: Guenaga FJ]]
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[[Category: Ofek, G]]
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[[Category: Kwong PD]]
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[[Category: Schief, W R]]
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[[Category: Ofek G]]
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[[Category: Skinner, J]]
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[[Category: Schief WR]]
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[[Category: Wyatt, R]]
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[[Category: Skinner J]]
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[[Category: Epitope]]
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[[Category: Wyatt R]]
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[[Category: Gp41]]
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[[Category: Graft]]
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[[Category: Hiv-1]]
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[[Category: Immune system]]
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[[Category: Monoclonal antibody]]
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[[Category: Re-elicitation]]
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[[Category: Scaffold]]
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[[Category: Sigma factor]]
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[[Category: Transplant]]
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[[Category: Vaccine design]]
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Current revision

HIV-1 antibody 2F5 in complex with epitope scaffold ES2

PDB ID 3lev

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