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4k2x
From Proteopedia
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==OxyS anhydrotetracycline hydroxylase from Streptomyces rimosus== | ==OxyS anhydrotetracycline hydroxylase from Streptomyces rimosus== | ||
| - | <StructureSection load='4k2x' size='340' side='right' caption='[[4k2x]], [[Resolution|resolution]] 2.55Å' scene=''> | + | <StructureSection load='4k2x' size='340' side='right'caption='[[4k2x]], [[Resolution|resolution]] 2.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4k2x]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4k2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_rimosus_subsp._rimosus_ATCC_10970 Streptomyces rimosus subsp. rimosus ATCC 10970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K2X FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k2x OCA], [https://pdbe.org/4k2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k2x RCSB], [https://www.ebi.ac.uk/pdbsum/4k2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k2x ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OXYS_STRR1 OXYS_STRR1] Involved in the biosynthesis of the antibiotics oxytetracycline and tetracycline. OxyS starts by catalyzing the stereospecific hydroxylation of anhydrotetracycline at C(6) position to yield 5a,11a-dehydrotetracycline (12-dehydrotetracycline). If the released product is captured by OxyR, it is reduced to tetracycline. However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C(5), producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR becomes oxytetracycline.<ref>PMID:23621493</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Streptomyces rimosus subsp. rimosus | + | [[Category: Large Structures]] |
| - | [[Category: Sawaya | + | [[Category: Streptomyces rimosus subsp. rimosus ATCC 10970]] |
| - | [[Category: Tang | + | [[Category: Sawaya MR]] |
| - | [[Category: Wang | + | [[Category: Tang Y]] |
| - | + | [[Category: Wang P]] | |
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Current revision
OxyS anhydrotetracycline hydroxylase from Streptomyces rimosus
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