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4ef8

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==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate==
==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate==
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<StructureSection load='4ef8' size='340' side='right' caption='[[4ef8]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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<StructureSection load='4ef8' size='340' side='right'caption='[[4ef8]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ef8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EF8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ef9|4ef9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0FI:N-PHENYLTHIOFORMAMIDE'>0FI</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHODH, lmjf16.0530, LMJF_16_0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [https://pdbe.org/4ef8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ef8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef8 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ef8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ef8 OCA], [http://pdbe.org/4ef8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ef8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ef8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ef8 ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q4QEW7_LEIMA Q4QEW7_LEIMA]
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Trypanosomatids consist of a large group of flagellated parasitic protozoa, including parasites from the genera Leishmania and Trypanosoma, responsible for causing infections in millions of humans worldwide and for which currently no appropriate therapy is available. The significance of pyrimidines in cellular metabolism makes their de novo and salvage pathways ideal druggable targets for pharmacological intervention and open an opportunity for pharmaceutical innovation. In the current review, we discuss the merits in targeting the enzyme dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme that catalyzes the fourth and only redox step in pyrimidine de novo biosynthesis, as a strategy for the development of efficient therapeutic strategies for trypanosomatid-related diseases. We also describe the advances and perspectives from the structural biology point of view in order to unravel the structure-function relationship of trypanosomatid DHODHs, and to identify and validate target sites for drug development.
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Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate.,Pinheiro MP, Emery FD, Nonato MC Curr Pharm Des. 2012 Oct 31. PMID:23116399<ref>PMID:23116399</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ef8" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]]
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leima]]
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[[Category: Large Structures]]
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[[Category: Emery, F S]]
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[[Category: Nonato, M C]]
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[[Category: Pinheiro, M P]]
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[[Category: Dihydroorotate dehydrogenase]]
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[[Category: Leishmania major]]
[[Category: Leishmania major]]
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[[Category: Oxidoreductase]]
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[[Category: Emery FS]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Nonato MC]]
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[[Category: Phenyl isothiocyanate]]
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[[Category: Pinheiro MP]]
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[[Category: Pyrd]]
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Current revision

Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate

PDB ID 4ef8

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