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3w6h

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==Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide==
==Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide==
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<StructureSection load='3w6h' size='340' side='right' caption='[[3w6h]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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<StructureSection load='3w6h' size='340' side='right'caption='[[3w6h]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w6h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W6H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W6H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>, <scene name='pdbligand=FLB:1-(2-ETHOXYETHOXY)-3,5-BIS(TRIFLUOROMETHYL)BENZENE'>FLB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.964&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w6i|3w6i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZM:5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>AZM</scene>, <scene name='pdbligand=FLB:1-(2-ETHOXYETHOXY)-3,5-BIS(TRIFLUOROMETHYL)BENZENE'>FLB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w6h OCA], [https://pdbe.org/3w6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w6h RCSB], [https://www.ebi.ac.uk/pdbsum/3w6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w6h ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w6h OCA], [http://pdbe.org/3w6h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w6h RCSB], [http://www.ebi.ac.uk/pdbsum/3w6h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w6h ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN]] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref>
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[https://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref>
==See Also==
==See Also==
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*[[Carbonic anhydrase|Carbonic anhydrase]]
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carbonate dehydratase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arita, K]]
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[[Category: Arita K]]
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[[Category: Ariyoshi, M]]
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[[Category: Ariyoshi M]]
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[[Category: Ashihara, E]]
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[[Category: Ashihara E]]
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[[Category: Hamachi, I]]
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[[Category: Hamachi I]]
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[[Category: Kioi, Y]]
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[[Category: Kioi Y]]
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[[Category: Morito, A]]
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[[Category: Morito A]]
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[[Category: Otani, J]]
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[[Category: Otani J]]
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[[Category: Shirakawa, M]]
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[[Category: Shirakawa M]]
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[[Category: Takaoka, Y]]
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[[Category: Takaoka Y]]
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[[Category: Tochio, H]]
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[[Category: Tochio H]]
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[[Category: 19f-nmr]]
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[[Category: Chemical biology]]
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[[Category: Lyase]]
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[[Category: Semisynthetic biosensor]]
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Current revision

Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide

PDB ID 3w6h

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