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3ipd

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==Helical extension of the neuronal SNARE complex into the membrane, spacegroup I 21 21 21==
==Helical extension of the neuronal SNARE complex into the membrane, spacegroup I 21 21 21==
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<StructureSection load='3ipd' size='340' side='right' caption='[[3ipd]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
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<StructureSection load='3ipd' size='340' side='right'caption='[[3ipd]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ipd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hd9 3hd9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IPD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ipd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hd9 3hd9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPD FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hd7|3hd7]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Vamp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Stx1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), SNAP-25 SPLICE VARIANT A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipd OCA], [https://pdbe.org/3ipd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipd RCSB], [https://www.ebi.ac.uk/pdbsum/3ipd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipd OCA], [http://pdbe.org/3ipd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ipd RCSB], [http://www.ebi.ac.uk/pdbsum/3ipd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
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[https://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipd_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipd_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3ipd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3ipd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Synaptosomal-associated protein|Synaptosomal-associated protein]]
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*[[Syntaxin|Syntaxin]]
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*[[Syntaxin 3D structures|Syntaxin 3D structures]]
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*[[Vesicle-associated membrane protein|Vesicle-associated membrane protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Jahn, R]]
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[[Category: Rattus norvegicus]]
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[[Category: Stein, A]]
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[[Category: Jahn R]]
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[[Category: Wahl, M C]]
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[[Category: Stein A]]
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[[Category: Weber, G]]
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[[Category: Wahl MC]]
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[[Category: 4-helical bundle]]
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[[Category: Weber G]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Exocytosis]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Membrane fusion]]
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[[Category: Membrane protein]]
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[[Category: Neurotransmitter transport]]
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[[Category: Palmitate]]
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[[Category: Phosphoprotein]]
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[[Category: Synapse]]
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[[Category: Synaptosome]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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Current revision

Helical extension of the neuronal SNARE complex into the membrane, spacegroup I 21 21 21

PDB ID 3ipd

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