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| | ==Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2== | | ==Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2== |
| - | <StructureSection load='3rnq' size='340' side='right' caption='[[3rnq]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='3rnq' size='340' side='right'caption='[[3rnq]], [[Resolution|resolution]] 1.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3rnq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3rnq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNQ FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1npu|1npu]], [[3bov|3bov]], [[3bp5|3bp5]], [[3bp6|3bp6]], [[3rnk|3rnk]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B7dc, Btdc, Cd273, Murine, Pdcd1lg2, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Pd1, Pdcd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnq OCA], [https://pdbe.org/3rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnq RCSB], [https://www.ebi.ac.uk/pdbsum/3rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnq ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnq OCA], [http://pdbe.org/3rnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rnq RCSB], [http://www.ebi.ac.uk/pdbsum/3rnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnq ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref> [[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). | + | [https://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref> |
| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Cell death protein|Cell death protein]] | + | *[[Cell death protein 3D structures|Cell death protein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Large Structures]] |
| - | [[Category: Almo, S C]] | + | [[Category: Mus musculus]] |
| - | [[Category: Lazar-Molnar, E]] | + | [[Category: Almo SC]] |
| - | [[Category: Nathenson, S G]] | + | [[Category: Lazar-Molnar E]] |
| - | [[Category: Ramagopal, U A]]
| + | [[Category: Nathenson SG]] |
| - | [[Category: B7-dc]]
| + | [[Category: Ramagopal UA]] |
| - | [[Category: Complex]] | + | |
| - | [[Category: Costimulatory]] | + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Pd-1-mutant]]
| + | |
| - | [[Category: Pd-l2]]
| + | |
| - | [[Category: Programmed death-1 ligand 2]]
| + | |
| Structural highlights
Function
PD1L2_MOUSE Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.[1] [2] [3]
See Also
References
- ↑ Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med. 2001 Apr 2;193(7):839-46. PMID:11283156
- ↑ Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001 Mar;2(3):261-8. PMID:11224527 doi:http://dx.doi.org/10.1038/85330
- ↑ Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med. 2003 May 5;197(9):1083-91. Epub 2003 Apr 28. PMID:12719480 doi:http://dx.doi.org/10.1084/jem.20021752
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