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4gbr

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Current revision (06:46, 26 October 2022) (edit) (undo)
 
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==N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor==
==N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor==
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<StructureSection load='4gbr' size='340' side='right' caption='[[4gbr]], [[Resolution|resolution]] 3.99&Aring;' scene=''>
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<StructureSection load='4gbr' size='340' side='right'caption='[[4gbr]], [[Resolution|resolution]] 3.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gbr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GBR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gbr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GBR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbr OCA], [https://pdbe.org/4gbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gbr RCSB], [https://www.ebi.ac.uk/pdbsum/4gbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbr ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbr OCA], [http://pdbe.org/4gbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gbr RCSB], [http://www.ebi.ac.uk/pdbsum/4gbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gbr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. [[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
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[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Adrenergic receptor|Adrenergic receptor]]
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*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
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*[[Beta-2 adrenergic receptor|Beta-2 adrenergic receptor]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bpt4]]
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[[Category: Escherichia virus T4]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Kobilka, B K]]
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[[Category: Kobilka BK]]
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[[Category: Weis, W I]]
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[[Category: Weis WI]]
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[[Category: Zou, Y]]
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[[Category: Zou Y]]
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[[Category: Transmembrane helice]]
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[[Category: Alkylation]]
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[[Category: Carazolol]]
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[[Category: G-protein coupled receptor]]
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[[Category: Membrane]]
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[[Category: Membrane protein-hydrolase complex]]
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[[Category: Signal transduction]]
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N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor

PDB ID 4gbr

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