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3atz

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==Crystal structure of TcOYE with pHBA==
==Crystal structure of TcOYE with pHBA==
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<StructureSection load='3atz' size='340' side='right' caption='[[3atz]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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<StructureSection load='3atz' size='340' side='right'caption='[[3atz]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3atz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ATZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3atz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ATZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HBA:P-HYDROXYBENZALDEHYDE'>HBA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3aty|3aty]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HBA:P-HYDROXYBENZALDEHYDE'>HBA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TcPGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atz OCA], [https://pdbe.org/3atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3atz RCSB], [https://www.ebi.ac.uk/pdbsum/3atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3atz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atz OCA], [http://pdbe.org/3atz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3atz RCSB], [http://www.ebi.ac.uk/pdbsum/3atz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3atz ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8I6L9_TRYCR Q8I6L9_TRYCR]
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Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2alpha) by TcOYE.
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Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi.,Okamoto N, Yamaguchi K, Mizohata E, Tokuoka K, Uchiyama N, Sugiyama S, Matsumura H, Inaka K, Urade Y, Inoue T J Biochem. 2011 Nov;150(5):563-8. doi: 10.1093/jb/mvr096. Epub 2011 Aug, 12. PMID:21840922<ref>PMID:21840922</ref>
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==See Also==
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*[[NADPH dehydrogenase|NADPH dehydrogenase]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3atz" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Trycr]]
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[[Category: Large Structures]]
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[[Category: Inaka, K]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Inoue, T]]
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[[Category: Inaka K]]
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[[Category: Matsumura, H]]
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[[Category: Inoue T]]
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[[Category: Mizohata, E]]
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[[Category: Matsumura H]]
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[[Category: Okamoto, N]]
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[[Category: Mizohata E]]
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[[Category: Sugiyama, S]]
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[[Category: Okamoto N]]
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[[Category: Tokuoka, K]]
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[[Category: Sugiyama S]]
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[[Category: Uchiyama, N]]
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[[Category: Tokuoka K]]
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[[Category: Urade, Y]]
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[[Category: Uchiyama N]]
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[[Category: Yamaguchi, K]]
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[[Category: Urade Y]]
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[[Category: Alpha/beta barrel]]
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[[Category: Yamaguchi K]]
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[[Category: Flavin mononucleotide]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Crystal structure of TcOYE with pHBA

PDB ID 3atz

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