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3bp8

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==Crystal structure of Mlc/EIIB complex==
==Crystal structure of Mlc/EIIB complex==
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<StructureSection load='3bp8' size='340' side='right' caption='[[3bp8]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='3bp8' size='340' side='right'caption='[[3bp8]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bp8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BP8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bp8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BP8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mlc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), ptsG, glcA, umg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp8 OCA], [http://pdbe.org/3bp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bp8 RCSB], [http://www.ebi.ac.uk/pdbsum/3bp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp8 OCA], [https://pdbe.org/3bp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bp8 RCSB], [https://www.ebi.ac.uk/pdbsum/3bp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTGCB_ECOLI PTGCB_ECOLI]] The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. This enzyme is also a chemoreceptor monitoring the environment for changes in sugar concentration.
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[https://www.uniprot.org/uniprot/MLC_ECOLI MLC_ECOLI] Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT.<ref>PMID:10464268</ref> <ref>PMID:11361067</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bp8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bp8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Phosphotransferase|Phosphotransferase]]
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*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: An, Y J]]
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[[Category: Large Structures]]
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[[Category: Cha, S S]]
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[[Category: An YJ]]
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[[Category: Jung, H I]]
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[[Category: Cha SS]]
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[[Category: Enzyme]]
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[[Category: Jung HI]]
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[[Category: Glucose signaling]]
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[[Category: Iicbglc]]
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[[Category: Inner membrane]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Mlc]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphotransferase system]]
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[[Category: Protein-protein interaction]]
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[[Category: Sugar transport]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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Current revision

Crystal structure of Mlc/EIIB complex

PDB ID 3bp8

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