2xcs

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==THE 2.1A CRYSTAL STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH GSK299423 AND DNA==
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==The 2.1A crystal structure of S. aureus Gyrase complex with GSK299423 and DNA==
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<StructureSection load='2xcs' size='340' side='right' caption='[[2xcs]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2xcs' size='340' side='right'caption='[[2xcs]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xcs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xcs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xct|2xct]], [[2xcr|2xcr]], [[2xco|2xco]], [[2xcq|2xcq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcs OCA], [https://pdbe.org/2xcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xcs RCSB], [https://www.ebi.ac.uk/pdbsum/2xcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xcs ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcs OCA], [http://pdbe.org/2xcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xcs RCSB], [http://www.ebi.ac.uk/pdbsum/2xcs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xcs ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
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[https://www.uniprot.org/uniprot/GYRA_STAAN GYRA_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897][https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xcs_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xcs_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Gyrase|Gyrase]]
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bax, B D]]
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[[Category: Large Structures]]
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[[Category: Brown, K K]]
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[[Category: Staphylococcus aureus subsp. aureus N315]]
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[[Category: Chan, P F]]
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[[Category: Synthetic construct]]
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[[Category: Eggleston, D S]]
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[[Category: Bax BD]]
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[[Category: Fosberry, A]]
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[[Category: Brown KK]]
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[[Category: Gentry, D R]]
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[[Category: Chan PF]]
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[[Category: Giordano, I]]
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[[Category: Eggleston DS]]
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[[Category: Gorrec, F]]
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[[Category: Fosberry A]]
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[[Category: Gwynn, M N]]
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[[Category: Gentry DR]]
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[[Category: Hann, M M]]
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[[Category: Giordano I]]
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[[Category: Hennessy, A]]
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[[Category: Gorrec F]]
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[[Category: Hibbs, M]]
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[[Category: Gwynn MN]]
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[[Category: Huang, J]]
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[[Category: Hann MM]]
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[[Category: Jones, E]]
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[[Category: Hennessy A]]
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[[Category: Jones, J]]
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[[Category: Hibbs M]]
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[[Category: Lewis, C J]]
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[[Category: Huang J]]
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[[Category: May, E W]]
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[[Category: Jones E]]
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[[Category: Pearson, N D]]
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[[Category: Jones J]]
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[[Category: Shen, C]]
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[[Category: Lewis CJ]]
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[[Category: Shillings, A]]
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[[Category: May EW]]
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[[Category: Singh, O]]
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[[Category: Pearson ND]]
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[[Category: Spitzfaden, C]]
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[[Category: Shen C]]
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[[Category: Theobald, A F]]
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[[Category: Shillings A]]
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[[Category: Wohlkonig, A]]
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[[Category: Singh O]]
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[[Category: Isomerase]]
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[[Category: Spitzfaden C]]
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[[Category: Type iia topoisomerase]]
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[[Category: Theobald AF]]
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[[Category: Wohlkonig A]]

Current revision

The 2.1A crystal structure of S. aureus Gyrase complex with GSK299423 and DNA

PDB ID 2xcs

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