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3wh2

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==Human Mincle in complex with citrate==
==Human Mincle in complex with citrate==
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<StructureSection load='3wh2' size='340' side='right' caption='[[3wh2]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='3wh2' size='340' side='right'caption='[[3wh2]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wh2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WH2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WH2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wh3|3wh3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLEC4E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wh2 OCA], [https://pdbe.org/3wh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wh2 RCSB], [https://www.ebi.ac.uk/pdbsum/3wh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wh2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wh2 OCA], [http://pdbe.org/3wh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wh2 RCSB], [http://www.ebi.ac.uk/pdbsum/3wh2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wh2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLC4E_HUMAN CLC4E_HUMAN]] C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
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[https://www.uniprot.org/uniprot/CLC4E_HUMAN CLC4E_HUMAN] C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Furukawa, A]]
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[[Category: Large Structures]]
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[[Category: Kamishikiryo, J]]
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[[Category: Furukawa A]]
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[[Category: Kanda, R]]
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[[Category: Kamishikiryo J]]
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[[Category: Maenaka, K]]
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[[Category: Kanda R]]
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[[Category: Miyake, Y]]
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[[Category: Maenaka K]]
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[[Category: Mori, D]]
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[[Category: Miyake Y]]
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[[Category: Okabe, Y]]
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[[Category: Mori D]]
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[[Category: Ose, T]]
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[[Category: Okabe Y]]
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[[Category: Toji, A]]
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[[Category: Ose T]]
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[[Category: Toyonaga, K]]
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[[Category: Toji A]]
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[[Category: Yamasaki, S]]
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[[Category: Toyonaga K]]
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[[Category: C-type lectin]]
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[[Category: Yamasaki S]]
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[[Category: Carbohydrate recognition]]
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[[Category: Glycolipid binding]]
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[[Category: Immune system]]
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[[Category: Plasmamembrane]]
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Current revision

Human Mincle in complex with citrate

PDB ID 3wh2

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