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3lrp

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==Crystal Structure of Plasmodium falciparum ADP-Ribosylation Factor 1==
==Crystal Structure of Plasmodium falciparum ADP-Ribosylation Factor 1==
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<StructureSection load='3lrp' size='340' side='right' caption='[[3lrp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3lrp' size='340' side='right'caption='[[3lrp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lrp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LRP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lro|3lro]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARF1, ARF, PLARF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrp OCA], [https://pdbe.org/3lrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrp RCSB], [https://www.ebi.ac.uk/pdbsum/3lrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrp OCA], [http://pdbe.org/3lrp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lrp RCSB], [http://www.ebi.ac.uk/pdbsum/3lrp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrp ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARF1_PLAFA ARF1_PLAFA]] GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).
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[https://www.uniprot.org/uniprot/ARF1_PLAF7 ARF1_PLAF7] Small GTPase involved in protein trafficking between different compartments (PubMed:21045287). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Regulates the transport of N-acylated AK2 to the parasitophorous vacuole membrane (PubMed:33604307). May be involved in the activation of lipid kinase PIP5K (PubMed:19171150).[UniProtKB:P84077]<ref>PMID:19171150</ref> <ref>PMID:21045287</ref> <ref>PMID:33604307</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plafa]]
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[[Category: Large Structures]]
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[[Category: Chattopadhyay, D]]
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[[Category: Plasmodium falciparum]]
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[[Category: Cook, W J]]
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[[Category: Chattopadhyay D]]
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[[Category: Adp-ribosylation factor]]
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[[Category: Cook WJ]]
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[[Category: Er-golgi transport]]
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[[Category: Golgi apparatus]]
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[[Category: Gtp-binding]]
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[[Category: Lipoprotein]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein trafficking]]
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[[Category: Protein transport]]
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[[Category: Signaling protein]]
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[[Category: Transport]]
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Current revision

Crystal Structure of Plasmodium falciparum ADP-Ribosylation Factor 1

PDB ID 3lrp

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