3acl

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==Crystal Structure of Human Pirin in complex with Triphenyl Compound==
==Crystal Structure of Human Pirin in complex with Triphenyl Compound==
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<StructureSection load='3acl' size='340' side='right' caption='[[3acl]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='3acl' size='340' side='right'caption='[[3acl]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3acl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ACL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ACL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3acl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ACL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ACL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3F1:N-{[4-(BENZYLOXY)PHENYL](METHYL)-LAMBDA~4~-SULFANYLIDENE}-4-METHYLBENZENESULFONAMIDE'>3F1</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j1l|1j1l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3F1:N-{[4-(BENZYLOXY)PHENYL](METHYL)-LAMBDA~4~-SULFANYLIDENE}-4-METHYLBENZENESULFONAMIDE'>3F1</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3acl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3acl OCA], [https://pdbe.org/3acl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3acl RCSB], [https://www.ebi.ac.uk/pdbsum/3acl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3acl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3acl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3acl OCA], [http://pdbe.org/3acl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3acl RCSB], [http://www.ebi.ac.uk/pdbsum/3acl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3acl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN]] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
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[https://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/3acl_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/3acl_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3acl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3acl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Miyazaki, I]]
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[[Category: Large Structures]]
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[[Category: Okumura, H]]
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[[Category: Miyazaki I]]
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[[Category: Osada, H]]
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[[Category: Okumura H]]
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[[Category: Simizu, S]]
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[[Category: Osada H]]
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[[Category: Complex]]
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[[Category: Simizu S]]
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[[Category: Cupin]]
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[[Category: Inhibitor]]
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[[Category: Iron]]
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[[Category: Metal binding protein]]
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Current revision

Crystal Structure of Human Pirin in complex with Triphenyl Compound

PDB ID 3acl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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