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3gnf

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==P1 Crystal structure of the N-terminal R1-R7 of murine MVP==
==P1 Crystal structure of the N-terminal R1-R7 of murine MVP==
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<StructureSection load='3gnf' size='340' side='right' caption='[[3gnf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3gnf' size='340' side='right'caption='[[3gnf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GNF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GNF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gf5|3gf5]], [[3gng|3gng]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mvp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gnf OCA], [https://pdbe.org/3gnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gnf RCSB], [https://www.ebi.ac.uk/pdbsum/3gnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gnf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gnf OCA], [http://pdbe.org/3gnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gnf RCSB], [http://www.ebi.ac.uk/pdbsum/3gnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gnf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
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[https://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/3gnf_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/3gnf_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Casanas, A]]
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[[Category: Mus musculus]]
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[[Category: Caston, J R]]
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[[Category: Casanas A]]
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[[Category: Fita, I]]
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[[Category: Caston JR]]
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[[Category: Luque, D]]
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[[Category: Fita I]]
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[[Category: Querol-Audi, J]]
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[[Category: Luque D]]
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[[Category: Uson, I]]
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[[Category: Querol-Audi J]]
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[[Category: Verdaguer, N]]
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[[Category: Uson I]]
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[[Category: Beta sheet]]
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[[Category: Verdaguer N]]
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[[Category: Phosphoprotein]]
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[[Category: Ribonucleoprotein]]
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[[Category: Structural protein]]
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Current revision

P1 Crystal structure of the N-terminal R1-R7 of murine MVP

PDB ID 3gnf

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