2wfm

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==CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT (H244A)==
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==Crystal structure of polyneuridine aldehyde esterase mutant (H244A)==
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<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='2wfm' size='340' side='right'caption='[[2wfm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Devilpepper Devilpepper]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wfl|2wfl]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [https://pdbe.org/2wfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [https://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://pdbe.org/2wfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE]] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
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[https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfm_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfm_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Devilpepper]]
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[[Category: Large Structures]]
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[[Category: Polyneuridine-aldehyde esterase]]
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[[Category: Rauvolfia serpentina]]
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[[Category: Hill, M]]
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[[Category: Hill M]]
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[[Category: Panjikar, S]]
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[[Category: Panjikar S]]
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[[Category: Stoeckigt, J]]
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[[Category: Stoeckigt J]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Yang, L]]
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[[Category: Yang L]]
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[[Category: Alkaloid metabolism]]
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[[Category: Hydrolase]]
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[[Category: Monoterpenoid indole alkaloid]]
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[[Category: Pnae]]
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[[Category: Serine esterase]]
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Current revision

Crystal structure of polyneuridine aldehyde esterase mutant (H244A)

PDB ID 2wfm

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