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2rru

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==Solution structure of the UBA omain of p62 and its interaction with ubiquitin==
==Solution structure of the UBA omain of p62 and its interaction with ubiquitin==
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<StructureSection load='2rru' size='340' side='right' caption='[[2rru]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2rru' size='340' side='right'caption='[[2rru]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2rru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RRU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2rru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRU FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3b0f|3b0f]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rru OCA], [https://pdbe.org/2rru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rru RCSB], [https://www.ebi.ac.uk/pdbsum/2rru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rru ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SQSTM1, A170, STAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rru OCA], [http://pdbe.org/2rru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rru RCSB], [http://www.ebi.ac.uk/pdbsum/2rru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rru ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
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[https://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Arita, K]]
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[[Category: Mus musculus]]
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[[Category: Hasegawa, J]]
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[[Category: Arita K]]
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[[Category: Isogai, S]]
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[[Category: Hasegawa J]]
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[[Category: Komatsu, M]]
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[[Category: Isogai S]]
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[[Category: Morimoto, D]]
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[[Category: Komatsu M]]
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[[Category: Shirakawa, M]]
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[[Category: Morimoto D]]
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[[Category: Sou, Y]]
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[[Category: Shirakawa M]]
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[[Category: Tanaka, K]]
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[[Category: Sou Y]]
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[[Category: Tenno, T]]
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[[Category: Tanaka K]]
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[[Category: Tochio, H]]
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[[Category: Tenno T]]
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[[Category: Unzai, S]]
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[[Category: Tochio H]]
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[[Category: Autophagy]]
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[[Category: Unzai S]]
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[[Category: P62/sqstm1]]
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[[Category: Protein binding]]
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[[Category: Uba domain]]
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[[Category: Ubiquitin]]
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Current revision

Solution structure of the UBA omain of p62 and its interaction with ubiquitin

PDB ID 2rru

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