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2wkh

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==Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7==
==Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7==
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<StructureSection load='2wkh' size='340' side='right' caption='[[2wkh]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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<StructureSection load='2wkh' size='340' side='right'caption='[[2wkh]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wkh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WKH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.791&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k55|1k55]], [[1k56|1k56]], [[1e3u|1e3u]], [[1fof|1fof]], [[2wgv|2wgv]], [[2wgi|2wgi]], [[1e4d|1e4d]], [[2wki|2wki]], [[1k4f|1k4f]], [[1ewz|1ewz]], [[2wgw|2wgw]], [[1k6s|1k6s]], [[1k4e|1k4e]], [[1k57|1k57]], [[1k54|1k54]], [[1k6r|1k6r]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wkh OCA], [https://pdbe.org/2wkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wkh RCSB], [https://www.ebi.ac.uk/pdbsum/2wkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wkh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wkh OCA], [http://pdbe.org/2wkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wkh RCSB], [http://www.ebi.ac.uk/pdbsum/2wkh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wkh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BLO10_PSEAI BLO10_PSEAI]] Hydrolyzes both carbenicillin and oxacillin.
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[https://www.uniprot.org/uniprot/BLO10_PSEAI BLO10_PSEAI] Hydrolyzes both carbenicillin and oxacillin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/2wkh_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/2wkh_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Bauvois, C]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Charlier, P]]
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[[Category: Bauvois C]]
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[[Category: Galleni, M]]
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[[Category: Charlier P]]
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[[Category: Guiet, R]]
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[[Category: Galleni M]]
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[[Category: Kerff, F]]
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[[Category: Guiet R]]
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[[Category: Sauvage, E]]
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[[Category: Kerff F]]
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[[Category: Vercheval, L]]
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[[Category: Sauvage E]]
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[[Category: Antibiotic resistance]]
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[[Category: Vercheval L]]
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[[Category: Class d beta-lactamase]]
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[[Category: Hydrolase]]
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[[Category: Plasmid encoded]]
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Current revision

Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7

PDB ID 2wkh

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