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2y5c

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==Structure of human ferredoxin 2 (Fdx2)in complex with 2Fe2S cluster==
==Structure of human ferredoxin 2 (Fdx2)in complex with 2Fe2S cluster==
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<StructureSection load='2y5c' size='340' side='right' caption='[[2y5c]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='2y5c' size='340' side='right'caption='[[2y5c]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y5c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y5C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y5C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5c OCA], [http://pdbe.org/2y5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y5c RCSB], [http://www.ebi.ac.uk/pdbsum/2y5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5c ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5c OCA], [https://pdbe.org/2y5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y5c RCSB], [https://www.ebi.ac.uk/pdbsum/2y5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5c ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FDX2_HUMAN FDX2_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADXL_HUMAN ADXL_HUMAN]] Essential for heme A and Fe/S protein biosynthesis.
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[https://www.uniprot.org/uniprot/FDX2_HUMAN FDX2_HUMAN] Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).[UniProtKB:Q9H1K1]<ref>PMID:28001042</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bernhardt, R]]
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[[Category: Large Structures]]
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[[Category: Essen, L O]]
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[[Category: Bernhardt R]]
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[[Category: Hannemann, F]]
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[[Category: Essen L-O]]
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[[Category: Hobler, A]]
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[[Category: Hannemann F]]
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[[Category: Keusgen, M]]
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[[Category: Hobler A]]
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[[Category: Lill, R]]
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[[Category: Keusgen M]]
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[[Category: Maestre-Reyna, M]]
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[[Category: Lill R]]
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[[Category: Molik, S]]
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[[Category: Maestre-Reyna M]]
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[[Category: Sheftel, A D]]
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[[Category: Molik S]]
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[[Category: Vorniscescu, D]]
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[[Category: Sheftel AD]]
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[[Category: Webert, H]]
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[[Category: Vorniscescu D]]
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[[Category: Electron transport]]
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[[Category: Webert H]]
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[[Category: Iron-sulfur cluster biogenesis]]
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Current revision

Structure of human ferredoxin 2 (Fdx2)in complex with 2Fe2S cluster

PDB ID 2y5c

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