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4q6l

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==LpoB C-terminal domain from Salmonella enterica (Native)==
==LpoB C-terminal domain from Salmonella enterica (Native)==
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<StructureSection load='4q6l' size='340' side='right' caption='[[4q6l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4q6l' size='340' side='right'caption='[[4q6l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4q6l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4q6l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6L FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q6v|4q6v]], [[4q6z|4q6z]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6l OCA], [http://pdbe.org/4q6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q6l RCSB], [http://www.ebi.ac.uk/pdbsum/4q6l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6l OCA], [https://pdbe.org/4q6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6l RCSB], [https://www.ebi.ac.uk/pdbsum/4q6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LPOB_SALTY LPOB_SALTY]] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity).
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[https://www.uniprot.org/uniprot/LPOB_SALTY LPOB_SALTY] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In bacteria, the synthesis of the protective peptidoglycan sacculus is a dynamic process that is tightly regulated at multiple levels. Recently, the lipoprotein co-factor LpoB has been found essential for the in-vivo function of the major peptidoglycan synthase PBP1b in Enterobacteriaceae. Herein, we reveal the crystal structures of Salmonella enterica and Escherichia coli LpoB. The LpoB protein can be modeled as a ball and tether, consisting of a disordered N-terminal region, followed by a compact globular C-terminal domain. Taken together, our structural data allows us to propose a revised model for LpoB mediated regulation of peptidoglycan synthesis.
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Structural insights into the lipoprotein outer-membrane regulator of penicillin-binding protein 1B.,King DT, Lameignere E, Strynadka NC J Biol Chem. 2014 May 7. pii: jbc.M114.565879. PMID:24808177<ref>PMID:24808177</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4q6l" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: King, D T]]
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[[Category: Large Structures]]
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[[Category: Strynadka, N C.J]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Activator of pbp1b]]
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[[Category: King DT]]
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[[Category: Lipidation]]
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[[Category: Strynadka NCJ]]
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[[Category: Lipoprotein]]
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[[Category: Mixed alpha-beta]]
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[[Category: Outer-membrane]]
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[[Category: Pbp1b]]
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[[Category: Protein binding]]
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Current revision

LpoB C-terminal domain from Salmonella enterica (Native)

PDB ID 4q6l

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