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3e1x

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==The Crystal Structure of Apo Prostasin at 1.7 Angstroms Resolution==
==The Crystal Structure of Apo Prostasin at 1.7 Angstroms Resolution==
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<StructureSection load='3e1x' size='340' side='right' caption='[[3e1x]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3e1x' size='340' side='right'caption='[[3e1x]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3e1x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E1X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3e1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E1X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1eon|1eon]], [[1eop|1eop]], [[3e16|3e16]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRSS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e1x OCA], [https://pdbe.org/3e1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e1x RCSB], [https://www.ebi.ac.uk/pdbsum/3e1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e1x ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e1x OCA], [http://pdbe.org/3e1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e1x RCSB], [http://www.ebi.ac.uk/pdbsum/3e1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e1x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRSS8_HUMAN PRSS8_HUMAN]] Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).<ref>PMID:15246975</ref> <ref>PMID:15474520</ref>
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[https://www.uniprot.org/uniprot/PRSS8_HUMAN PRSS8_HUMAN] Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).<ref>PMID:15246975</ref> <ref>PMID:15474520</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e1x_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e1x_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Harris, J L]]
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[[Category: Large Structures]]
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[[Category: Hornsby, M]]
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[[Category: Harris JL]]
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[[Category: Lesley, S A]]
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[[Category: Hornsby M]]
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[[Category: Shipway, A]]
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[[Category: Lesley SA]]
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[[Category: Spraggon, G]]
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[[Category: Shipway A]]
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[[Category: Cell membrane]]
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[[Category: Spraggon G]]
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[[Category: Channel activating protease]]
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[[Category: Enac]]
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[[Category: Glycoprotein]]
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[[Category: Hcap-1]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Prostasin]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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Current revision

The Crystal Structure of Apo Prostasin at 1.7 Angstroms Resolution

PDB ID 3e1x

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