4e1b
From Proteopedia
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==Re-refinement of PDB entry 2EQA - SUA5 protein from Sulfolobus tokodaii with bound threonylcarbamoyladenylate== | ==Re-refinement of PDB entry 2EQA - SUA5 protein from Sulfolobus tokodaii with bound threonylcarbamoyladenylate== | ||
| - | <StructureSection load='4e1b' size='340' side='right' caption='[[4e1b]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='4e1b' size='340' side='right'caption='[[4e1b]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4e1b]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4e1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E1B FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TXA:THREONYLCARBAMOYLADENYLATE'>TXA</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e1b OCA], [https://pdbe.org/4e1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e1b RCSB], [https://www.ebi.ac.uk/pdbsum/4e1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e1b ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SUA5_SULTO SUA5_SULTO] Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity). Probably catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Shows ATP hydrolysis activity in vitro, producing AMP.<ref>PMID:22383337</ref> |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An ancient reaction vessel: TobZ carbamoylates the antibiotic tobramycin to form nebramycin 5'. The YrdC-like domain (blue) catalyzes the formation of the novel intermediate carbamoyladenylate, which is channeled through a common "reaction chamber" to the Kae1-like domain (brown), site of carbamoyl transfer. | ||
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| + | The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction.,Parthier C, Gorlich S, Jaenecke F, Breithaupt C, Brauer U, Fandrich U, Clausnitzer D, Wehmeier UF, Bottcher C, Scheel D, Stubbs MT Angew Chem Int Ed Engl. 2012 Mar 1. doi: 10.1002/anie.201108896. PMID:22383337<ref>PMID:22383337</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4e1b" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Boettcher | + | [[Category: Sulfurisphaera tokodaii str. 7]] |
| - | [[Category: Braeuer | + | [[Category: Boettcher C]] |
| - | [[Category: Breithaupt | + | [[Category: Braeuer U]] |
| - | [[Category: Clausnitzer | + | [[Category: Breithaupt C]] |
| - | [[Category: Fandrich | + | [[Category: Clausnitzer D]] |
| - | [[Category: Goerlich | + | [[Category: Fandrich U]] |
| - | [[Category: Jaenecke | + | [[Category: Goerlich S]] |
| - | [[Category: Parthier | + | [[Category: Jaenecke F]] |
| - | [[Category: Scheel | + | [[Category: Parthier C]] |
| - | [[Category: Stubbs | + | [[Category: Scheel D]] |
| - | [[Category: Wehmeier | + | [[Category: Stubbs MT]] |
| - | + | [[Category: Wehmeier UF]] | |
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Current revision
Re-refinement of PDB entry 2EQA - SUA5 protein from Sulfolobus tokodaii with bound threonylcarbamoyladenylate
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