4j7p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:53, 20 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of Saccharomyces cerevisiae Sfh3==
==Crystal structure of Saccharomyces cerevisiae Sfh3==
-
<StructureSection load='4j7p' size='340' side='right' caption='[[4j7p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='4j7p' size='340' side='right'caption='[[4j7p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4j7p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J7P FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4j7p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7P FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j7q|4j7q]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N1158, PDR16, SFH3, YNL231C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7p OCA], [https://pdbe.org/4j7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7p RCSB], [https://www.ebi.ac.uk/pdbsum/4j7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7p ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7p OCA], [http://pdbe.org/4j7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j7p RCSB], [http://www.ebi.ac.uk/pdbsum/4j7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7p ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PDR16_YEAST PDR16_YEAST]] Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover.<ref>PMID:9890948</ref> <ref>PMID:10848624</ref>
+
[https://www.uniprot.org/uniprot/PDR16_YEAST PDR16_YEAST] Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover.<ref>PMID:9890948</ref> <ref>PMID:10848624</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Sec14 family homologs are the major yeast phosphatidylinositol/phosphatidylcholine transfer proteins regulating lipid metabolism and vesicle trafficking. The structure of Saccharomyces cerevisiae Sfh3 displays a conserved Sec14 scaffold and reveals determinants for the specific recognition of phosphatidylinositol ligand. Apo-Sfh3 forms a dimer through the hydrophobic interaction of gating helices. Binding of phosphatidylinositol leads to dissociation of the dimer into monomers in a reversible manner. This study suggests that the substrate induced dimer-monomer transformation is an essential part of lipid transfer cycles by Sfh3.
+
-
 
+
-
Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles.,Yang H, Tong J, Leonard TA, Im YJ FEBS Lett. 2013 Jun 5;587(11):1610-6. doi: 10.1016/j.febslet.2013.04.009. Epub, 2013 Apr 18. PMID:23603387<ref>PMID:23603387</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4j7p" style="background-color:#fffaf0;"></div>
+
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Baker's yeast]]
+
[[Category: Large Structures]]
-
[[Category: Im, Y J]]
+
[[Category: Saccharomyces cerevisiae S288C]]
-
[[Category: Yang, H]]
+
[[Category: Im YJ]]
-
[[Category: Lipid transport]]
+
[[Category: Yang H]]
-
[[Category: Phosphatidylinositol]]
+
-
[[Category: Sec14 scaffold]]
+

Current revision

Crystal structure of Saccharomyces cerevisiae Sfh3

PDB ID 4j7p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4j7p"
Personal tools