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4mt6

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==Crystal structure of closed inactive collybistin==
==Crystal structure of closed inactive collybistin==
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<StructureSection load='4mt6' size='340' side='right' caption='[[4mt6]], [[Resolution|resolution]] 5.50&Aring;' scene=''>
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<StructureSection load='4mt6' size='340' side='right'caption='[[4mt6]], [[Resolution|resolution]] 5.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mt6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MT6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MT6 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mt7|4mt7]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.501&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt6 OCA], [http://pdbe.org/4mt6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mt6 RCSB], [http://www.ebi.ac.uk/pdbsum/4mt6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mt6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt6 OCA], [https://pdbe.org/4mt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mt6 RCSB], [https://www.ebi.ac.uk/pdbsum/4mt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mt6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARHG9_RAT ARHG9_RAT]] Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.<ref>PMID:10607391</ref> <ref>PMID:11727829</ref> <ref>PMID:15215304</ref>
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[https://www.uniprot.org/uniprot/ARHG9_RAT ARHG9_RAT] Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.<ref>PMID:10607391</ref> <ref>PMID:11727829</ref> <ref>PMID:15215304</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The formation of neuronal synapses and the dynamic regulation of their efficacy depend on the assembly of the postsynaptic neurotransmitter receptor apparatus. Receptor recruitment to inhibitory GABAergic and glycinergic synapses is controlled by the scaffold protein gephyrin and the adaptor protein collybistin. We derived new insights into the structure of collybistin and used these to design biochemical, cell biological, and genetic analyses of collybistin function. Our data define a collybistin-based protein interaction network that controls the gephyrin content of inhibitory postsynapses. Within this network, collybistin can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides. This function of collybistin is regulated by binding of the adhesion protein neuroligin-2, which stabilizes the open/active conformation of collybistin at the postsynaptic plasma membrane by competing with an intramolecular interaction in collybistin that favors the closed/inactive conformation. By linking trans-synaptic neuroligin-dependent adhesion and phosphoinositide signaling with gephyrin recruitment, the collybistin-based regulatory switch mechanism represents an integrating regulatory node in the formation and function of inhibitory postsynapses.
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A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.,Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N EMBO J. 2014 Jul 30. pii: e201488143. PMID:25082542<ref>PMID:25082542</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4mt6" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Rho guanine nucleotide exchange factor|Rho guanine nucleotide exchange factor]]
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*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Schindelin, H]]
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[[Category: Large Structures]]
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[[Category: Schneeberger, D]]
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[[Category: Rattus norvegicus]]
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[[Category: Closed conformation]]
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[[Category: Schindelin H]]
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[[Category: Protein binding]]
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[[Category: Schneeberger D]]

Current revision

Crystal structure of closed inactive collybistin

PDB ID 4mt6

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