3qwl

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==Crystal structure of human TBC1 domain family member 7==
==Crystal structure of human TBC1 domain family member 7==
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<StructureSection load='3qwl' size='340' side='right' caption='[[3qwl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3qwl' size='340' side='right'caption='[[3qwl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QWL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBC1D7, HSPC239, TBC7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwl OCA], [http://pdbe.org/3qwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qwl RCSB], [http://www.ebi.ac.uk/pdbsum/3qwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwl OCA], [https://pdbe.org/3qwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwl RCSB], [https://www.ebi.ac.uk/pdbsum/3qwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN]] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref>
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[https://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Guan, X]]
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[[Category: Edwards AM]]
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[[Category: Landry, R]]
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[[Category: Guan X]]
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[[Category: Park, H]]
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[[Category: Landry R]]
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[[Category: Structural genomic]]
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[[Category: Park H]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Tong, Y]]
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[[Category: Tong Y]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Wernimont, A K]]
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[[Category: Wernimont AK]]
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[[Category: Hydrolase activator]]
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[[Category: Rab gtpase activation]]
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[[Category: Sgc]]
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[[Category: Tbc domain]]
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Current revision

Crystal structure of human TBC1 domain family member 7

PDB ID 3qwl

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