4ehr
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
==Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide== | ==Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide== | ||
| - | <StructureSection load='4ehr' size='340' side='right' caption='[[4ehr]], [[Resolution|resolution]] 2.09Å' scene=''> | + | <StructureSection load='4ehr' size='340' side='right'caption='[[4ehr]], [[Resolution|resolution]] 2.09Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHR FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [https://pdbe.org/4ehr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [https://www.ebi.ac.uk/pdbsum/4ehr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehr ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ==See Also== | |
| - | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |
| - | + | ||
| - | + | ||
| - | + | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Banfi | + | [[Category: Large Structures]] |
| - | [[Category: Borzilleri | + | [[Category: Banfi P]] |
| - | [[Category: Cai | + | [[Category: Borzilleri RM]] |
| - | [[Category: Galvani | + | [[Category: Cai Z]] |
| - | [[Category: Lippy | + | [[Category: Galvani A]] |
| - | [[Category: Lombardo | + | [[Category: Lippy J]] |
| - | [[Category: Menichincheri | + | [[Category: Lombardo LJ]] |
| - | [[Category: Modugno | + | [[Category: Menichincheri M]] |
| - | [[Category: Naglich | + | [[Category: Modugno M]] |
| - | [[Category: Penhallow | + | [[Category: Naglich J]] |
| - | [[Category: Perez | + | [[Category: Penhallow B]] |
| - | [[Category: Sack | + | [[Category: Perez HL]] |
| - | [[Category: Schmidt | + | [[Category: Sack J]] |
| - | [[Category: Schroeder | + | [[Category: Schmidt RJ]] |
| - | [[Category: Tebben | + | [[Category: Schroeder GM]] |
| - | [[Category: Wei | + | [[Category: Tebben A]] |
| - | [[Category: Yan | + | [[Category: Wei D]] |
| - | [[Category: Zhang | + | [[Category: Yan C]] |
| - | + | [[Category: Zhang L]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide
| |||||||||||
Categories: Homo sapiens | Large Structures | Banfi P | Borzilleri RM | Cai Z | Galvani A | Lippy J | Lombardo LJ | Menichincheri M | Modugno M | Naglich J | Penhallow B | Perez HL | Sack J | Schmidt RJ | Schroeder GM | Tebben A | Wei D | Yan C | Zhang L
