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4lyl

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==Crystal structure of uracil-DNA glycosylase from cod (Gadus morhua) in complex with the proteinaceous inhibitor UGI==
==Crystal structure of uracil-DNA glycosylase from cod (Gadus morhua) in complex with the proteinaceous inhibitor UGI==
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<StructureSection load='4lyl' size='340' side='right' caption='[[4lyl]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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<StructureSection load='4lyl' size='340' side='right'caption='[[4lyl]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lyl]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LYL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lyl]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PBS2 Bacillus phage PBS2] and [https://en.wikipedia.org/wiki/Gadus_morhua Gadus morhua]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LYL FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1okb|1okb]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lyl OCA], [https://pdbe.org/4lyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lyl RCSB], [https://www.ebi.ac.uk/pdbsum/4lyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lyl ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lyl OCA], [http://pdbe.org/4lyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lyl RCSB], [http://www.ebi.ac.uk/pdbsum/4lyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lyl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q9I983_GADMO Q9I983_GADMO]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).[RuleBase:RU003780][HAMAP-Rule:MF_03166] [[http://www.uniprot.org/uniprot/UNGI_BPPB2 UNGI_BPPB2]] This protein binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.
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[https://www.uniprot.org/uniprot/Q9I983_GADMO Q9I983_GADMO] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).[RuleBase:RU003780][HAMAP-Rule:MF_03166]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[DNA glycosylase|DNA glycosylase]]
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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*[[Uracil-DNA glycosylase|Uracil-DNA glycosylase]]
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*[[Uracil glycosylase inhibitor|Uracil glycosylase inhibitor]]
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*[[Uracil-DNA glycosylase inhibitor|Uracil-DNA glycosylase inhibitor]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Uridine nucleosidase]]
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[[Category: Bacillus phage PBS2]]
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[[Category: Assefa, N G]]
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[[Category: Gadus morhua]]
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[[Category: Johnson, K A]]
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[[Category: Large Structures]]
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[[Category: Leiros, H K.S]]
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[[Category: Assefa NG]]
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[[Category: Moe, E]]
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[[Category: Johnson KA]]
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[[Category: Niiranen, L M.K]]
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[[Category: Leiros H-KS]]
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[[Category: Smalas, A O]]
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[[Category: Moe E]]
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[[Category: Willassen, N P]]
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[[Category: Niiranen LMK]]
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[[Category: Alpha/beta fold]]
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[[Category: Smalas AO]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Willassen NP]]
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[[Category: Hydrolysis]]
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[[Category: Intracellular]]
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Current revision

Crystal structure of uracil-DNA glycosylase from cod (Gadus morhua) in complex with the proteinaceous inhibitor UGI

PDB ID 4lyl

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