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4azm

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==Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413==
==Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413==
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<StructureSection load='4azm' size='340' side='right' caption='[[4azm]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='4azm' size='340' side='right'caption='[[4azm]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4azm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AZM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4azm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=T4B:((2-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC+ACID'>T4B</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b56|1b56]], [[1jjj|1jjj]], [[4azn|4azn]], [[4azo|4azo]], [[4azp|4azp]], [[4azq|4azq]], [[4azr|4azr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=T4B:((2-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC+ACID'>T4B</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4azm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azm OCA], [http://pdbe.org/4azm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4azm RCSB], [http://www.ebi.ac.uk/pdbsum/4azm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4azm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4azm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azm OCA], [https://pdbe.org/4azm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4azm RCSB], [https://www.ebi.ac.uk/pdbsum/4azm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4azm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
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[https://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Fatty acid-binding protein|Fatty acid-binding protein]]
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Deutsch, D]]
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[[Category: Large Structures]]
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[[Category: Kaczocha, M]]
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[[Category: Deutsch D]]
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[[Category: Li, H]]
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[[Category: Kaczocha M]]
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[[Category: Ojima, I]]
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[[Category: Li H]]
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[[Category: Sanson, B]]
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[[Category: Ojima I]]
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[[Category: Sun, J]]
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[[Category: Sanson B]]
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[[Category: Wang, T]]
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[[Category: Sun J]]
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[[Category: Beta-barrel]]
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[[Category: Wang T]]
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[[Category: Beta-clamshell]]
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[[Category: Domain swapping]]
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[[Category: Endocannabinoid]]
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[[Category: Lipid binding protein]]
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[[Category: Lipid carrier protein]]
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Current revision

Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413

PDB ID 4azm

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