3py9

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==X-ray structural studies of the entire extra-cellular region of the Ser/Thr kinase PrkC from Staphylococcus aureus==
==X-ray structural studies of the entire extra-cellular region of the Ser/Thr kinase PrkC from Staphylococcus aureus==
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<StructureSection load='3py9' size='340' side='right' caption='[[3py9]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3py9' size='340' side='right'caption='[[3py9]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3py9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PY9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3py9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PY9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EU:EUROPIUM+ION'>EU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SAV1220 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EU:EUROPIUM+ION'>EU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3py9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3py9 OCA], [http://pdbe.org/3py9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3py9 RCSB], [http://www.ebi.ac.uk/pdbsum/3py9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3py9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3py9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3py9 OCA], [https://pdbe.org/3py9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3py9 RCSB], [https://www.ebi.ac.uk/pdbsum/3py9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3py9 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A0H3JZ56_STAAM A0A0H3JZ56_STAAM]
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Bacterial Ser/Thr kinases modulate a wide number of cellular processes. PrkC kinase from human pathogen Staphylococcus aureus was also shown to induce germination of Bacillus subtilis spores, in response to cell-wall muropeptides. The presence of muropeptides in the bacterial extra-cellular milieu is a strong signal that growing conditions are promising. We report here the x-ray structure of the entire extra-cellular region of PrkC from Staphylococcus aureus. This structure reveals that the extra-cellular region of PrkC, EC-PrkC, is a linear modular structure, composed of three PASTA domains and an unpredicted C-terminal domain, which presents the typical features of adhesive proteins. Using several solution techniques, we also evidenced that EC-PrkC shows no tendency to dimerise even in the presence of high concentrations of muropeptides. X-ray structural results obtained here provide molecular clues into the mechanism of muropeptide-induced PrkC activation.
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X-ray structural studies of the entire extra-cellular region of the Ser/Thr kinase PrkC from Staphylococcus aureus.,Ruggiero A, Squeglia F, Marasco D, Marchetti R, Molinaro A, Berisio R Biochem J. 2011 Jan 6. PMID:21208192<ref>PMID:21208192</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3py9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staam]]
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[[Category: Large Structures]]
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[[Category: Berisio, R]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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[[Category: Marasco, D]]
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[[Category: Berisio R]]
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[[Category: Marchetti, R]]
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[[Category: Marasco D]]
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[[Category: Molinaro, A]]
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[[Category: Marchetti R]]
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[[Category: Ruggiero, A]]
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[[Category: Molinaro A]]
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[[Category: Squeglia, F]]
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[[Category: Ruggiero A]]
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[[Category: Kinase]]
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[[Category: Squeglia F]]
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[[Category: Membrane]]
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[[Category: Muropeptide binding]]
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[[Category: Pasta]]
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[[Category: Phosphorylation]]
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[[Category: Transferase]]
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X-ray structural studies of the entire extra-cellular region of the Ser/Thr kinase PrkC from Staphylococcus aureus

PDB ID 3py9

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