4j1t

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==Crystal structure of Thermus thermophilus transhydrogenase heterotrimeric complex of the Alpha1 subunit dimer with the NADP binding domain (domain III) of the Beta subunit in P2(1)==
==Crystal structure of Thermus thermophilus transhydrogenase heterotrimeric complex of the Alpha1 subunit dimer with the NADP binding domain (domain III) of the Beta subunit in P2(1)==
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<StructureSection load='4j1t' size='340' side='right' caption='[[4j1t]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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<StructureSection load='4j1t' size='340' side='right'caption='[[4j1t]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4j1t]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4j1t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xlt|1xlt]], [[4j16|4j16]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TT_C1780 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=262724 THET2])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1t OCA], [https://pdbe.org/4j1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1t RCSB], [https://www.ebi.ac.uk/pdbsum/4j1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1t ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(P)(+)_transhydrogenase_(Re/Si-specific) NAD(P)(+) transhydrogenase (Re/Si-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.1.2 1.6.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1t OCA], [http://pdbe.org/4j1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j1t RCSB], [http://www.ebi.ac.uk/pdbsum/4j1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1t ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q72GS0_THET2 Q72GS0_THET2]] The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity).[PIRNR:PIRNR000204]
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[https://www.uniprot.org/uniprot/Q72GR8_THET2 Q72GR8_THET2]
==See Also==
==See Also==
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*[[NAD(P) transhydrogenase|NAD(P) transhydrogenase]]
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*[[NAD(P) transhydrogenase 3D structures|NAD(P) transhydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thet2]]
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[[Category: Large Structures]]
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[[Category: Briccio, L A.Schurig]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Gennis, R B]]
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[[Category: Gennis RB]]
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[[Category: Leung, J]]
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[[Category: Leung J]]
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[[Category: Stout, C D]]
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[[Category: Schurig Briccio LA]]
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[[Category: Yamaguchi, M]]
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[[Category: Stout CD]]
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[[Category: Complex of alpha1 subunit dimer with domain iii of beta subunit]]
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[[Category: Yamaguchi M]]
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[[Category: Domain iii binds to alpha1]]
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[[Category: Nad bound to alpha1]]
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[[Category: Nadp bound to domain iii]]
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[[Category: Oxidoreductase]]
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[[Category: Soluble components of nicotinamide nucleotide transhydrogenase]]
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Current revision

Crystal structure of Thermus thermophilus transhydrogenase heterotrimeric complex of the Alpha1 subunit dimer with the NADP binding domain (domain III) of the Beta subunit in P2(1)

PDB ID 4j1t

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