4hmn

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==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)==
==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)==
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<StructureSection load='4hmn' size='340' side='right' caption='[[4hmn]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4hmn' size='340' side='right'caption='[[4hmn]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hmn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HMN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hmn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HMN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16J:[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL](MORPHOLIN-4-YL)METHANONE'>16J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16J:[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL](MORPHOLIN-4-YL)METHANONE'>16J</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmn OCA], [http://pdbe.org/4hmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hmn RCSB], [http://www.ebi.ac.uk/pdbsum/4hmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmn OCA], [https://pdbe.org/4hmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hmn RCSB], [https://www.ebi.ac.uk/pdbsum/4hmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
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[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Prostaglandin F synthase|Prostaglandin F synthase]]
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*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Atwell, G J]]
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[[Category: Large Structures]]
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[[Category: Brooke, D G]]
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[[Category: Atwell GJ]]
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[[Category: Denny, W A]]
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[[Category: Brooke DG]]
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[[Category: Flanagan, J U]]
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[[Category: Denny WA]]
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[[Category: Heinrich, D M]]
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[[Category: Flanagan JU]]
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[[Category: Jamieson, S M.F]]
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[[Category: Heinrich DM]]
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[[Category: Owen, P J]]
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[[Category: Jamieson SMF]]
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[[Category: Raynham, T]]
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[[Category: Owen PJ]]
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[[Category: Rigoreau, L J.M]]
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[[Category: Raynham T]]
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[[Category: Samlal, S S]]
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[[Category: Rigoreau LJM]]
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[[Category: Schroeder, E]]
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[[Category: Samlal SS]]
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[[Category: Silva, S]]
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[[Category: Schroeder E]]
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[[Category: Soudy, C]]
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[[Category: Silva S]]
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[[Category: Trivier, E]]
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[[Category: Soudy C]]
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[[Category: Turnbull, A P]]
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[[Category: Trivier E]]
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[[Category: Aldo-keto reductase]]
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[[Category: Turnbull AP]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim-barrel]]
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Current revision

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)

PDB ID 4hmn

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