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2woz

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==THE NOVEL BETA-PROPELLER OF THE BTB-KELCH PROTEIN KRP1 PROVIDES THE BINDING SITE FOR LASP-1 THAT IS NECESSARY FOR PSEUDOPODIA EXTENSION==
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==The novel beta-propeller of the BTB-Kelch protein Krp1 provides the binding site for Lasp-1 that is necessary for pseudopodia extension==
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<StructureSection load='2woz' size='340' side='right' caption='[[2woz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='2woz' size='340' side='right'caption='[[2woz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2woz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2woz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2woz OCA], [http://pdbe.org/2woz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2woz RCSB], [http://www.ebi.ac.uk/pdbsum/2woz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2woz ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2woz OCA], [https://pdbe.org/2woz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2woz RCSB], [https://www.ebi.ac.uk/pdbsum/2woz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2woz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KBTBA_RAT KBTBA_RAT]] Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Required for pseudopod elongation in transformed cells.<ref>PMID:10713668</ref>
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[https://www.uniprot.org/uniprot/KLH41_RAT KLH41_RAT] Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.[UniProtKB:A2AUC9]<ref>PMID:10713668</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2woz_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2woz_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Kelch-like protein|Kelch-like protein]]
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*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Gray, C H]]
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[[Category: Rattus norvegicus]]
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[[Category: Mcgarry, L C]]
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[[Category: Gray CH]]
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[[Category: Ozanne, B W]]
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[[Category: McGarry LC]]
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[[Category: Riboldi-Tunnicliffe, A]]
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[[Category: Ozanne BW]]
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[[Category: Spence, H J]]
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[[Category: Riboldi-Tunnicliffe A]]
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[[Category: Cell projection]]
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[[Category: Spence HJ]]
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[[Category: Cytoskeleton]]
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[[Category: Invasion and metastasis]]
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[[Category: Kelch domain]]
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[[Category: Kelch repeat]]
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[[Category: Protein binding]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Ubl protein folding]]
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Current revision

The novel beta-propeller of the BTB-Kelch protein Krp1 provides the binding site for Lasp-1 that is necessary for pseudopodia extension

PDB ID 2woz

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