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4apy

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==Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis==
==Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis==
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<StructureSection load='4apy' size='340' side='right' caption='[[4apy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4apy' size='340' side='right'caption='[[4apy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4apy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4APY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4apy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4apy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apy OCA], [http://pdbe.org/4apy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4apy RCSB], [http://www.ebi.ac.uk/pdbsum/4apy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4apy ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apy OCA], [https://pdbe.org/4apy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apy RCSB], [https://www.ebi.ac.uk/pdbsum/4apy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apy ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP125_MYCS2 CP125_MYCS2] Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.<ref>PMID:23489718</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus smegmatis trevisan 1889]]
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[[Category: Large Structures]]
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[[Category: Fernandez, E Garcia]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Frank, D J]]
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[[Category: Frank DJ]]
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[[Category: Kells, P M]]
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[[Category: Garcia Fernandez E]]
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[[Category: Lopez, J L.Garcia]]
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[[Category: Garcia Lopez JL]]
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[[Category: Montellano, P R.Ortiz de]]
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[[Category: Kells PM]]
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[[Category: Podust, L M]]
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[[Category: Ortiz de Montellano PR]]
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[[Category: Cholesterol metabolism]]
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[[Category: Podust LM]]
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[[Category: Oxidoreductase]]
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Current revision

Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis

PDB ID 4apy

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