4dhr

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==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening==
==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening==
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<StructureSection load='4dhr' size='340' side='right' caption='[[4dhr]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='4dhr' size='340' side='right'caption='[[4dhr]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dhr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DHR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DHR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y04:(2-{2-[(2-CHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>Y04</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y04:(2-{2-[(2-CHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>Y04</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tol|3tol]], [[3t0m|3t0m]], [[3u9x|3u9x]], [[4dhm|4dhm]], [[4dhn|4dhn]], [[4dho|4dho]], [[4dhp|4dhp]], [[4dhq|4dhq]], [[4dhs|4dhs]], [[4dht|4dht]], [[4dhu|4dhu]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dhr OCA], [https://pdbe.org/4dhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dhr RCSB], [https://www.ebi.ac.uk/pdbsum/4dhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dhr ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME1, SFN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dhr OCA], [http://pdbe.org/4dhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dhr RCSB], [http://www.ebi.ac.uk/pdbsum/4dhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dhr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[14-3-3 protein|14-3-3 protein]]
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Kohlbacher, O]]
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[[Category: Large Structures]]
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[[Category: Ottmann, C]]
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[[Category: Kohlbacher O]]
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[[Category: Roeglin, L]]
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[[Category: Ottmann C]]
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[[Category: Thiel, P]]
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[[Category: Roeglin L]]
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[[Category: Adapter protein]]
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[[Category: Thiel P]]
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[[Category: Phosphoprotein binding]]
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[[Category: Protein binding-inhibitor complex]]
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Current revision

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening

PDB ID 4dhr

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