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4oct

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==Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate==
==Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate==
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<StructureSection load='4oct' size='340' side='right' caption='[[4oct]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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<StructureSection load='4oct' size='340' side='right'caption='[[4oct]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oct]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OCT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oct]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OCT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALKBH5, ABH5, OFOXD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oct OCA], [http://pdbe.org/4oct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oct RCSB], [http://www.ebi.ac.uk/pdbsum/4oct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oct ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oct OCA], [https://pdbe.org/4oct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oct RCSB], [https://www.ebi.ac.uk/pdbsum/4oct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oct ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref>
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[https://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Dioxygenase|Dioxygenase]]
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Cerovina, T]]
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[[Category: Bountra C]]
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[[Category: Chao, X]]
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[[Category: Cerovina T]]
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[[Category: Dong, A]]
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[[Category: Chao X]]
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[[Category: Edwards, A M]]
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[[Category: Dong A]]
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[[Category: He, H]]
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[[Category: Edwards AM]]
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[[Category: Liu, K]]
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[[Category: He H]]
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[[Category: Min, J]]
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[[Category: Liu K]]
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[[Category: Structural genomic]]
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[[Category: Min J]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Oxidoreductase]]
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[[Category: Rna demethylase]]
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[[Category: Sgc]]
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Current revision

Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate

PDB ID 4oct

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