4hbd
From Proteopedia
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==Crystal structure of KANK2 ankyrin repeats== | ==Crystal structure of KANK2 ankyrin repeats== | ||
| - | <StructureSection load='4hbd' size='340' side='right' caption='[[4hbd]], [[Resolution|resolution]] 1.72Å' scene=''> | + | <StructureSection load='4hbd' size='340' side='right'caption='[[4hbd]], [[Resolution|resolution]] 1.72Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4hbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBD FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [https://pdbe.org/4hbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [https://www.ebi.ac.uk/pdbsum/4hbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbd ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref> |
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| + | ==See Also== | ||
| + | *[[Ankyrin repeat domain-containing protein 3D structures|Ankyrin repeat domain-containing protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Cerovina | + | [[Category: Cerovina T]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: El Bakkouri M]] |
| - | [[Category: | + | [[Category: Min J]] |
| - | [[Category: Tempel | + | [[Category: Tempel W]] |
| - | [[Category: Xu | + | [[Category: Xu C]] |
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| - | + | ||
Current revision
Crystal structure of KANK2 ankyrin repeats
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Cerovina T | Edwards AM | El Bakkouri M | Min J | Tempel W | Xu C
