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3t3a

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==Crystal structure of H107R mutant of extracellular domain of mouse receptor NKR-P1A==
==Crystal structure of H107R mutant of extracellular domain of mouse receptor NKR-P1A==
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<StructureSection load='3t3a' size='340' side='right' caption='[[3t3a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3t3a' size='340' side='right'caption='[[3t3a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3t3a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T3A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3t3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T3A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m9z|3m9z]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Klrb1a, Ly55, Ly55a, Nkrp1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t3a OCA], [https://pdbe.org/3t3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t3a RCSB], [https://www.ebi.ac.uk/pdbsum/3t3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t3a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t3a OCA], [http://pdbe.org/3t3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t3a RCSB], [http://www.ebi.ac.uk/pdbsum/3t3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t3a ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLRBA_MOUSE KLRBA_MOUSE]] Plays a stimulatory role on natural killer (NK) cell cytotoxicity.<ref>PMID:16751398</ref>
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[https://www.uniprot.org/uniprot/KLRBA_MOUSE KLRBA_MOUSE] Plays a stimulatory role on natural killer (NK) cell cytotoxicity.<ref>PMID:16751398</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the H107R variant of the extracellular domain of the mouse natural killer cell receptor NKR-P1A has been determined by X-ray diffraction at 2.3 A resolution from a merohedrally twinned crystal. Unlike the structure of the wild-type receptor in space group I4(1)22 with a single chain per asymmetric unit, the crystals of the variant belonged to space group I4(1) with a dimer in the asymmetric unit. Different degrees of merohedral twinning were detected in five data sets collected from different crystals. The mutation does not have a significant impact on the overall structure, but led to the binding of an additional phosphate ion at the interface of the molecules.
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Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 A resolution.,Kolenko P, Rozbesky D, Vanek O, Bezouska K, Hasek J, Dohnalek J Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1519-23., Epub 2011 Nov 30. PMID:22139156<ref>PMID:22139156</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3t3a" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Bezouska, K]]
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[[Category: Mus musculus]]
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[[Category: Dohnalek, J]]
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[[Category: Bezouska K]]
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[[Category: Hasek, J]]
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[[Category: Dohnalek J]]
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[[Category: Kolenko, P]]
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[[Category: Hasek J]]
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[[Category: Rozbesky, D]]
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[[Category: Kolenko P]]
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[[Category: C-type lectin-like domain]]
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[[Category: Rozbesky D]]
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[[Category: Domain swapping]]
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[[Category: Natural killer cell receptor]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane receptor]]
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[[Category: Twinning]]
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Current revision

Crystal structure of H107R mutant of extracellular domain of mouse receptor NKR-P1A

PDB ID 3t3a

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