This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2wgh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:55, 13 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
==HUMAN RIBONUCLEOTIDE REDUCTASE R1 SUBUNIT (RRM1) IN COMPLEX WITH DATP AND MG.==
+
==Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg.==
-
<StructureSection load='2wgh' size='340' side='right' caption='[[2wgh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='2wgh' size='340' side='right'caption='[[2wgh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2wgh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGH FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2wgh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGH FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgh OCA], [http://pdbe.org/2wgh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wgh RCSB], [http://www.ebi.ac.uk/pdbsum/2wgh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgh ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgh OCA], [https://pdbe.org/2wgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgh RCSB], [https://www.ebi.ac.uk/pdbsum/2wgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
+
[https://www.uniprot.org/uniprot/RIR1_HUMAN RIR1_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgh_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgh_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 31: Line 31:
==See Also==
==See Also==
-
*[[Ribonucleotide reductase|Ribonucleotide reductase]]
+
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Ribonucleoside-diphosphate reductase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Berg, S Van Den]]
+
[[Category: Berglund H]]
-
[[Category: Berglund, H]]
+
[[Category: Bountra C]]
-
[[Category: Bountra, C]]
+
[[Category: Collins R]]
-
[[Category: Collins, R]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M]]
+
[[Category: Flodin S]]
-
[[Category: Flodin, S]]
+
[[Category: Flores A]]
-
[[Category: Flores, A]]
+
[[Category: Graslund S]]
-
[[Category: Graslund, S]]
+
[[Category: Hammarstrom M]]
-
[[Category: Hammarstrom, M]]
+
[[Category: Johansson A]]
-
[[Category: Johansson, A]]
+
[[Category: Johansson I]]
-
[[Category: Johansson, I]]
+
[[Category: Karlberg T]]
-
[[Category: Karlberg, T]]
+
[[Category: Kotenyova T]]
-
[[Category: Kotenyova, T]]
+
[[Category: Kotzsch A]]
-
[[Category: Kotzsch, A]]
+
[[Category: Kragh-Nielsen T]]
-
[[Category: Kragh-Nielsen, T]]
+
[[Category: Moche M]]
-
[[Category: Moche, M]]
+
[[Category: Nordlund P]]
-
[[Category: Nordlund, P]]
+
[[Category: Nyman T]]
-
[[Category: Nyman, T]]
+
[[Category: Persson C]]
-
[[Category: Persson, C]]
+
[[Category: Sagemark J]]
-
[[Category: Sagemark, J]]
+
[[Category: Schueler H]]
-
[[Category: Schueler, H]]
+
[[Category: Schutz P]]
-
[[Category: Schutz, P]]
+
[[Category: Siponen MI]]
-
[[Category: Siponen, M I]]
+
[[Category: Svensson L]]
-
[[Category: Svensson, L]]
+
[[Category: Thorsell AG]]
-
[[Category: Thorsell, A G]]
+
[[Category: Tresaugues L]]
-
[[Category: Tresaugues, L]]
+
[[Category: Van Den Berg S]]
-
[[Category: Weigelt, J]]
+
[[Category: Weigelt J]]
-
[[Category: Welin, R M]]
+
[[Category: Welin RM]]
-
[[Category: Wisniewska, M]]
+
[[Category: Wisniewska M]]
-
[[Category: Allosteric enzyme]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Dna replication]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg.

PDB ID 2wgh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wgh"
Personal tools