3s3s

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==Transglutaminase 2 in complex with a novel inhibitor==
==Transglutaminase 2 in complex with a novel inhibitor==
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<StructureSection load='3s3s' size='340' side='right' caption='[[3s3s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3s3s' size='340' side='right'caption='[[3s3s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3s3s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3s3s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene>, <scene name='pdbligand=XW1:(2S)-2-AMINO-7-ETHOXY-7-OXOHEPTANOIC+ACID'>XW1</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XW1:(2S)-2-AMINO-7-ETHOXY-7-OXOHEPTANOIC+ACID'>XW1</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2q3z|2q3z]], [[3s3j|3s3j]], [[3s3p|3s3p]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3s OCA], [https://pdbe.org/3s3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3s RCSB], [https://www.ebi.ac.uk/pdbsum/3s3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3s ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-glutamine_gamma-glutamyltransferase Protein-glutamine gamma-glutamyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.13 2.3.2.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3s OCA], [http://pdbe.org/3s3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s3s RCSB], [http://www.ebi.ac.uk/pdbsum/3s3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3s ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TGM2_HUMAN TGM2_HUMAN]] Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
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[https://www.uniprot.org/uniprot/TGM2_HUMAN TGM2_HUMAN] Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Protein-glutamine gamma-glutamyltransferase]]
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[[Category: Large Structures]]
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[[Category: Heine, A]]
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[[Category: Synthetic construct]]
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[[Category: Klebe, G]]
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[[Category: Heine A]]
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[[Category: Lindemann, I]]
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[[Category: Klebe G]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Lindemann I]]
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[[Category: Transglutaminase]]
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Transglutaminase 2 in complex with a novel inhibitor

PDB ID 3s3s

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