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1m43

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[[Image:1m43.gif|left|200px]]
 
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{{Structure
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==Crystal structure of PMII in complex with pepstatin a to 2.4 A==
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|PDB= 1m43 |SIZE=350|CAPTION= <scene name='initialview01'>1m43</scene>, resolution 2.40&Aring;
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<StructureSection load='1m43' size='340' side='right'caption='[[1m43]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=IHN:3-HYDROXY-4-ISOBUTYL-4-[AMINOCARBONYLETHYL(AMINO+CARBONYL-2-HYDROXY-5-METHYLHEXYL)TRI(AMINOCARBONYL+ISOBUTYL)]BUTANOIC+ACID'>IHN</scene>
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<table><tr><td colspan='2'>[[1m43]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M43 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m43 OCA], [https://pdbe.org/1m43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m43 RCSB], [https://www.ebi.ac.uk/pdbsum/1m43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m43 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1sme|1SME]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m43 OCA], [http://www.ebi.ac.uk/pdbsum/1m43 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m43 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:8844673, PubMed:11782538, PubMed:15574427). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m43_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m43 ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF PMII IN COMPLEX WITH PEPSTATIN A TO 2.4 A'''
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==See Also==
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*[[Plasmepsin|Plasmepsin]]
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== References ==
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==About this Structure==
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<references/>
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1M43 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M43 OCA].
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__TOC__
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[[Category: Plasmepsin II]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Single protein]]
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[[Category: Streptomyces argenteolus subsp. toyonakensis]]
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[[Category: Asojo, O A.]]
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[[Category: Asojo OA]]
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[[Category: Gulnik, S.]]
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[[Category: Gulnik S]]
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[[Category: Silva, A M.]]
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[[Category: Silva AM]]
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[[Category: plasmepsin ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:10:55 2008''
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Current revision

Crystal structure of PMII in complex with pepstatin a to 2.4 A

PDB ID 1m43

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