|
|
| (One intermediate revision not shown.) |
| Line 1: |
Line 1: |
| | | | |
| | ==2.2A resolution structure of Proteasome Assembly Chaperone Hsm3== | | ==2.2A resolution structure of Proteasome Assembly Chaperone Hsm3== |
| - | <StructureSection load='4fp7' size='340' side='right' caption='[[4fp7]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4fp7' size='340' side='right'caption='[[4fp7]], [[Resolution|resolution]] 2.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4fp7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FP7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4fp7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FP7 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSM3, YBR272C, YBR1740 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fp7 OCA], [http://pdbe.org/4fp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fp7 RCSB], [http://www.ebi.ac.uk/pdbsum/4fp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fp7 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fp7 OCA], [https://pdbe.org/4fp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fp7 RCSB], [https://www.ebi.ac.uk/pdbsum/4fp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fp7 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HSM3_YEAST HSM3_YEAST]] Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).<ref>PMID:9539417</ref> <ref>PMID:10681182</ref> <ref>PMID:10681183</ref> <ref>PMID:15450405</ref> <ref>PMID:19446322</ref> <ref>PMID:19217412</ref> <ref>PMID:19412159</ref> | + | [https://www.uniprot.org/uniprot/HSM3_YEAST HSM3_YEAST] Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).<ref>PMID:9539417</ref> <ref>PMID:10681182</ref> <ref>PMID:10681183</ref> <ref>PMID:15450405</ref> <ref>PMID:19446322</ref> <ref>PMID:19217412</ref> <ref>PMID:19412159</ref> |
| | + | |
| | + | ==See Also== |
| | + | *[[DNA mismatch repair protein 3D structures|DNA mismatch repair protein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Baker's yeast]] | + | [[Category: Large Structures]] |
| - | [[Category: Battaile, K P]] | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: Lovell, S]] | + | [[Category: Battaile KP]] |
| - | [[Category: Roelofs, J]] | + | [[Category: Lovell S]] |
| - | [[Category: Singh, R]] | + | [[Category: Roelofs J]] |
| - | [[Category: Zolkiewski, M]] | + | [[Category: Singh R]] |
| - | [[Category: Chaperone]]
| + | [[Category: Zolkiewski M]] |
| - | [[Category: Hsm3]]
| + | |
| - | [[Category: Proteasome]]
| + | |
| Structural highlights
Function
HSM3_YEAST Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).[1] [2] [3] [4] [5] [6] [7]
See Also
References
- ↑ Fedorova IV, Gracheva LM, Kovaltzova SV, Evstuhina TA, Alekseev SY, Korolev VG. The yeast HSM3 gene acts in one of the mismatch repair pathways. Genetics. 1998 Mar;148(3):963-73. PMID:9539417
- ↑ Merker JD, Datta A, Kolodner RD, Petes TD. The yeast HSM3 gene is not involved in DNA mismatch repair in rapidly dividing cells. Genetics. 2000 Jan;154(1):491-3. PMID:10681182
- ↑ Fedorova IV, Kovaltzova SV, Korolev VG. The yeast HSM3 gene is involved in DNA mismatch repair in slowly dividing cells. Genetics. 2000 Jan;154(1):495-6. PMID:10681183
- ↑ Fedorova IV, Kovaltzova SV, Gracheva LM, Evstuhina TA, Korolev VG. Requirement of HSM3 gene for spontaneous mutagenesis in Saccharomyces cerevisiae. Mutat Res. 2004 Oct 4;554(1-2):67-75. PMID:15450405 doi:10.1016/j.mrfmmm.2004.03.003
- ↑ Funakoshi M, Tomko RJ Jr, Kobayashi H, Hochstrasser M. Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell. 2009 May 29;137(5):887-99. Epub 2009 May 14. PMID:19446322 doi:S0092-8674(09)00526-1
- ↑ Le Tallec B, Barrault MB, Guerois R, Carre T, Peyroche A. Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome. Mol Cell. 2009 Feb 13;33(3):389-99. doi: 10.1016/j.molcel.2009.01.010. PMID:19217412 doi:10.1016/j.molcel.2009.01.010
- ↑ Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y, Lee BH, Zhang F, Shi Y, Gygi SP, Finley D. Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature. 2009 Jun 11;459(7248):861-5. PMID:19412159 doi:nature08063
|
