1m4r

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[[Image:1m4r.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22==
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|PDB= 1m4r |SIZE=350|CAPTION= <scene name='initialview01'>1m4r</scene>, resolution 2.00&Aring;
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<StructureSection load='1m4r' size='340' side='right'caption='[[1m4r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1m4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4R FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4r OCA], [https://pdbe.org/1m4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4r RCSB], [https://www.ebi.ac.uk/pdbsum/1m4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4r ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4r OCA], [http://www.ebi.ac.uk/pdbsum/1m4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m4r RCSB]</span>
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[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN] Cytokine that contributes to the inflammatory response in vivo.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4r ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.
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==About this Structure==
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1M4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4R OCA].
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==Reference==
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Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12176383 12176383]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Colau, D.]]
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[[Category: Colau D]]
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[[Category: Dumoutier, L.]]
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[[Category: Dumoutier L]]
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[[Category: Nagem, R A.P.]]
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[[Category: Nagem RAP]]
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[[Category: Ogata, C.]]
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[[Category: Ogata C]]
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[[Category: Polikarpov, I.]]
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[[Category: Polikarpov I]]
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[[Category: Renauld, J C.]]
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[[Category: Renauld J-C]]
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[[Category: crystal structure]]
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[[Category: cytokine]]
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[[Category: interferon-gamma]]
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[[Category: interleukin-10 (il-10)]]
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[[Category: interleukin-22 (il-22)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:14 2008''
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Current revision

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22

PDB ID 1m4r

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